Professor, Director
Jiangsu Stem Cell Key Laboratory
Jiangsu Institute of Clinical Immunology
E-mail: xueguangzh@126.com
Major Research Directions:
1. Stem cell and medical bio-material.
2. Tumor immunity and autoimmune disease
Professional positions & Education:
2011- present Director of Jiangsu Institute of Clinical Immunology
2003- present Director of Jiangsu Stem Cell Key Laboratory
2000- present Director of Medical Biotechnology Institute of Soochow University
2000- 2012 Vice President of Soochow University
Director of the Key Research Institute of Clinical Immunlogy
No.1 Affiliated Hospital of Suzhou University
1993-1999 Professor of Immunology
Director of Immunology Research Unit
Director of Biotechnology Institute
Vice President of Suzhou Medical College
1991-1993 Post-doctorate
Blood & Tumor Research Section
Nante Medical College, France
1990-1991 Assistant Professor of Immunology
Director of Immunology Research Unit
Deputy director of Biotechnology Institute
1986-1990 Doctor’s degree of Molecular Biology and Immunology
Montpellier University of Science and Technology, France
1982-1986 Lecturer
Teaching and Research Group of Pathology and Physiology
Suzhou Medical College
1978-1982 Master’s degree of Immunology
Teaching and Research Group of Pathology and Physiology
Suzhou Medical College
1974-1978 Bachelor’s degree of Medicine
Suzhou Medical College
Fellowship:
1993-1996 recipient of National Excellent Youth Scientific Fund
1996-2000 recipient of National Outstanding Youth Scientific Fund
Professional Organizations:
Standing Committee member of Chinese Immunology Association
Chairman of Jiangsu Immunology Association
Chairman of Jiangsu Microbiology and Immunology Branch
Member of Jiangsu Branch, Chinese Medical Association
Member of American Immunology Association
Member of American Hematology Association
Publications:
1. Gu Y, Xue Q, Chen Y, Yu G, Qing M, Shen Y, Wang M, Shi Q, Zhang X*.Different roles of PD-L1 and FasL in immunomodulation mediated by human placenta-derived mesenchymal stem cells[J]. Human Immunology, 2013, 74(3):267–276.
2. Xue Q, Luan XY, Gu YZ, Wu HY, Zhang GB, Yu GH, Zhu HT, Wang M, Dong W, Geng YJ, Zhang XG*. The negative co-signaling molecule b7-h4 is expressed by human bone marrow-derived mesenchymal stem cells and mediates its T-cell modulatory activity. Stem Cells Dev. 2010;19:27-38.
3. Zhang F, Lu Q, Yue X, Zuo B, Qin M, Li F, Kaplan DL, Zhang X*. 2015. Regeneration of high-quality silk fibroin fiber by wet spinning from CaCl2-formic acid solvent. Acta Biomater 12: 139-45.
4. Zhang F, Lu Q, Ming J, Dou H, Liu Z, Zuo B*, Qin M, Li F, Kaplan DL, Zhang X*. Silk dissolution and regeneration at the nanofibril scale. J Mater Chem B 2014;2:3879-3885.
5. Zhang F, Lu Q, Ming J, Dou H, Liu Z, Zuo B*, Qin M, Li F, Kaplan DL, Zhang X*. Silk dissolution and regeneration at the nanofibril scale. J Mater Chem B 2014;2:3879-3885.
6. Juean Jiang, Jianhua Jiang, Cuiping Liu, Guangbo Zhang, Li Gao, Yongjing Chen, Ranran Zhu, Ting Wang, Fengmin Wang, Xueguang Zhang*, Qun Xue. Enhancement of Membrane B7-H3 Costimulatory Molecule but Reduction of Its Soluble Form in Multiple Sclerosis. Journal of Clinical Immunology. 2013; 33: 118-126.
7. Bin Shen ,Jun Zhang,Hongya Wu,Jianying Wang ,Ke Ma,Zheng Li,Zhang X*. Generation of gene-modified mice via Cas9/RNA-mediated gene targeting[J]. Cell Research, 2013, 23.
8. Yan-zheng Gu ,Qun Xue,Yong-jing Chen, Ge-Hua Yu, Ming-de Qing,Yu Shen, Ming-yuan Wang,Qin Shi,Xue-Guang Zhang*.Different roles of PD-L1 and FasL in immunomodulation mediated by human planceta-derived mesenchymal stem cells. Human Immunology. 2013;74:267-276
9. Liang Zhang , Hongya Wu , Gang Li , Chuanyang Sun , Hui Song , Jinmei Li , Tianhang Zhai , Lv Huang , Chuansheng Hou , Weipeng Wang , Bin Zhou , Shaohua Chen , Binfeng Lu , Desheng Lu, Xueguang Zhang*. The costimulatory molecule B7-H4 promote tumor progression and cell proliferation through translocating into nucleus. Oncogene. 2013, 32:5347–5358.
10. Wang F, Yan T, Chen L, Chen X, Liu T, Shen S, Li T, Gao L, Wang T, Sun J, Liu C, Wu H, Zhang X*, Chen L. Involvement of Inducible Costimulator Ligand (ICOSL) Expression in Thyroid Tissue in Hyperthyroidism of Graves’ Disease Patients. Journal of Clinical Immunology. 2012;32;1253-1261.
11. Weipeng Wang,* Jing Sun,* Fang Li, Rui Li, Yongping Gu, Cuiping Liu, Peng Yang, Ming Zhu, Lujun Chen, Wenyan Tian, Huan Zhou, Yong Mao, Liang Zhang, Jingting Jiang, Changping Wu, Dong Hua, Weichang Chen, Binfeng Lu, Jingfang Ju, and Xueguang Zhang*. A frequent somatic mutation in CD274 3’-UTR 1 leads to protein 2 over-expression in gastric cancer by disrupting miR-570 binding. Hum Mutat. 2012;33: 480-484.
12. Xin Gao, Yibei Zhu, Gang Li, Haitao Huang, Guangbo Zhang, Fengming Wang, Jing Sun, Qianting Yang, Xueguang Zhang*, Binfeng Lu. TIM-3 Expression Characterizes Regulatory T Cells in Tumor Tissues and Is Associated with Lung Cancer Progression. PLoS ONE. 2012; 7(2): e30676.
13. Liwen Chen, Yibei Zhu, Guangbo Zhang, Chao Gao, Weixue Zhong and Xueguang Zhang*. CD83-stimulated monocytes suppress T-cell immune responses through production of PGE2. Pro Nat1.Acad.Sci.USA. 2011;108: 18778-18783.
14. Jing Sun, Fengqing Fu, Wenchao Gu, Ruhong Yan, Guangbo Zhang, Zhiyong Shen, Yinghui Zhou, Han Wang, Bairong Shen, Xueguang Zhang*. Origination of New Immunological Functions in the Costimulatory Molecule B7-H3: The Role of Exon Duplication in Evolution of the Immune System. PLoS ONE. 2011; 6(9):e24751. doi: 10.1371
15. Lu-jun Chen, Jing Sun, Hong-ya Wu, Shu-ming Zhou, Yan Tan, Ming Tan, Bao-en Shan, Bin-feng Lu and Xue-guang Zhang*. B7-H4 expression associates with cancer progression and predicts patient’s survival in human esophageal squamous cell carcinoma. Cancer Immunol Immunother. 2011;60: 1047-1055.
16. Jiang J, Zhu Y, Wu C, Shen Y, Wei W, Chen L, Zheng X, Sun J, Lu B, Zhang X*. Tumor expression of B7-H4 predicts poor survival of patients suffering from gastric cancer. Cancer Immunol Immunother. 2010;59:1707-1714.
17. Zhu Y, Ju S, Chen E, Dai S, Li C, Morel P, Liu L, Zhang X*, Lu B. T-bet and Eomesodermin are required for T cell-mediated antitumor immune responses. J Immunol. 2010;185:3174-3183.
18. Zhang G, Wang J, Kelly J, Gu G, Hou J, Zhou Y, Redmond HP, Wang JH, Zhang X*. B7-h3 augments the inflammatory response and is associated with human sepsis. J Immunol. 2010;185:3677-3684.
19. Sun J, Chen LJ, Zhang GB, Jiang JT, Zhu M, Tan Y, Wang HT, Lu BF, Zhang XG*. Clinical significance and regulation of the costimulatory molecule B7-H3 in human colorectal carcinoma. Cancer Immunol Immunother. 2010;59:1163-1171.
* Corresponding author
Representative Research Supports:
2007CB512402, Zhang (In charge) 10/01/2012 – 10/31/2017
Sub–topics of National Basic Research Program of China(973 Program)
“Molecular mechanisms of self-antigen recognition by the immune system and effect on autoimmunity”
2006AA02A254, Zhang (In charge) 01/01/2009 – 12/31/2010
Sub–topics of National high-tech research development plan (863 plan)
“Optimization and reconstruction of humanized antibody”
30930085, Zhang (In charge) 01/01/2010 – 12/31/2013
National Natural Science Foundation of China
“Biological significance of PD-1/PD-L1 pathway affected self immunologic injury of RA”