Ying Xu, MD, PhD
Distinguished Professor, CAM-SU Genomic Resource Center, Soochow University
Suzhou, Jiangsu, China,215123
Tel: 86-512-65883781, Fax: 86-512-65883562
E-mail: yingxu@suda.edu.cn
Education Background:
PhD in Cell Biology, University of Tokyo, Japan, 2001
MD in Molecular Pathology, Saitama Medical University, Japan, 1996
MS in Radiation Medicine, Suzhou Medical College, China, 1988
BSc in Pharmacology, Shanghai Medial University, China, 1985
Professional Activity
2015- President of Chinese Society for Biological Rhythms
2010-2014 Member of study section in Chinese National Science Foundation: life science
2007- Ad hoc Program committee for international conferences for Genetics, circadian clock, sleep etc.
Research Interests:
Circadian systems provide a fitness advantage to organisms by improving their ability to react to cyclic factors in the environment, especially in response to light/dark cycles. The research goal of our laboratory is to understand the mechanisms of the circadian clock at molecular, genomic and behaviour levels.
Honors & Awards:
2008 National Outstanding Youth Project by Natural Science Foundation of China
2010 Chief scientist of National Key Basic Research Program of China
2016 The Newton Advanced Fellowship by the Royal Society
Selected Publications:
Xing, L., An, Y., Shi, G., Yan, J., Xie, P., Qu, Z., Zhang, Z., Liu, Z., Pan, D., and Xu, Y. (2017). Correlated evolution between CK1delta Protein and the Serine-rich Motif Contributes to Regulating the Mammalian Circadian Clock. The Journal of biological chemistry 292, 161-171.
Wang L, Zhou F, Zhang P, Wang H, Qu Z, Jia P, Yao Z, Shen G, Li G, Zhao G, Li J, Mao Y, Xie Z, Xu W, Xu Y, Xu Y (2017). Human type H vessels are a sensitive biomarker of bone mass. Cell Death Dis 8, e2760.
Dong Z, Huang M, Liu Z, Xie P, Dong Y, Wu X, Qu Z, Shen B, Huang X, Zhang T, Li J, Liu J, Yanase T, Zhou C, Xu Y (2016). Focused screening of mitochondrial metabolism reveals a crucial role for a tumor suppressor Hbp1 in ovarian reserve. Cell death and differentiation 23, 1602-1614.
Hirano A, Shi G, Jones CR, Lipzen A, Pennacchio LA, Xu Y, Hallows WC, McMahon T, Yamazaki M, Ptacek LJ, Fu YH (2016). A Cryptochrome 2 mutation yields advanced sleep phase in humans. Elife 5.
Qu Z, Zhang H, Huang M, Shi G, Liu Z, Xie P, Li H, Wang W, Xu G, Zhang Y, Yang L, Huang G, Takahashi JS, Zhang WJ, Xu Y (2016). Loss of ZBTB20 impairs circadian output and leads to unimodal behavioral rhythms. Elife 5.
Shi G, Xie P, Qu Z, Zhang Z, Dong Z, An Y, Xing L, Liu Z, Dong Y, Xu G, Yang L, Liu Y, Xu Y (2016). Distinct Roles of HDAC3 in the Core Circadian Negative Feedback Loop Are Critical for Clock Function. Cell Rep 14, 823-834.
Wang, Y., Stokes, A., Duan, Z., Hui, J., Xu, Y., Chen, Y., Chen, H.W., Lam, K., and Zhou, C.J. (2016). LDL Receptor-Related Protein 6 Modulates Ret Proto-Oncogene Signaling in Renal Development and Cystic Dysplasia. Journal of the American Society of Nephrology : JASN 27, 417-427.
Zhang L, Hirano A, Hsu PK, Jones CR, Sakai N, Okuro M, McMahon T, Yamazaki M, Xu Y, Saigoh N, Saigoh K, Lin ST, Kaasik K, Nishino S, Ptacek LJ, Fu YH (2016). A PERIOD3 variant causes a circadian phenotype and is associated with a seasonal mood trait. Proceedings of the National Academy of Sciences of the United States of America 113, E1536-1544.
Liu Z, Huang M, Wu X, Shi G, Xing L, Dong Z, Qu Z, Yan J, Yang L, Panda S, Xu Y (2014). PER1 phosphorylation specifies feeding rhythm in mice. Cell Rep 7, 1509-1520.
Yan, J., Shi, G., Zhang, Z., Wu, X., Liu, Z., Xing, L., Qu, Z., Dong, Z., Yang, L., and Xu, Y. (2014). An intensity ratio of interlocking loops determines circadian period length. Nucleic acids research 42, 10278-10287.
Shi G, Xing L, Liu Z, Qu Z, Wu X, Dong Z, Wang X, Gao X, Huang M, Yan J, Yang L, Liu Y, Ptacek LJ, Xu Y (2013). Dual roles of FBXL3 in the mammalian circadian feedback loops are important for period determination and robustness of the clock. Proceedings of the National Academy of Sciences of the United States of America 110, 4750-4755.
Yan, J., Shi, G., Zhang, Z., Wu, X., Liu, Z., Xing, L., Qu, Z., Dong, Z., Yang, L., and Xu, Y. (2014). An intensity ratio of interlocking loops determines circadian period length. Nucleic acids research 42, 10278-10287.
Wu, X., Wang, B., Dong, Z., Zhou, S., Liu, Z., Shi, G., Cao, Y., and Xu, Y. (2013). A NANOS3 mutation linked to protein degradation causes premature ovarian insufficiency. Cell Death Dis 4, e825.
Lee HY, Nakayama J, Xu Y, Fan X, Karouani M, Shen Y, Pothos EN, Hess EJ, Fu YH, Edwards RH, Ptacek LJ (2012). Dopamine dysregulation in a mouse model of paroxysmal nonkinesigenic dyskinesia. The Journal of clinical investigation 122, 507-518.
Gu X, Xing L, Shi G, Liu Z, Wang X, Qu Z, Wu X, Dong Z, Gao X, Liu G, Yang L, Xu Y (2012). The circadian mutation PER2(S662G) is linked to cell cycle progression and tumorigenesis. Cell death and differentiation 19, 397-405.
Wu X, Liu Z, Shi G, Xing L, Wang X, Gu X, Qu Z, Dong Z, Xiong J, Gao X, Zhang C, Xu Y (2011). The circadian clock influences heart performance. Journal of biological rhythms 26, 402-411.
Wang, X., Gao, X., and Xu, Y. (2011). MAGED1: molecular insights and clinical implications. Ann Med 43, 347-355.
Tao, W., Chen, S., Shi, G., Guo, J., Xu, Y., and Liu, C. (2011). SWItch/sucrose nonfermentable (SWI/SNF) complex subunit BAF60a integrates hepatic circadian clock and energy metabolism. Hepatology 54, 1410-1420.
Wang, X., Tang, J., Xing, L., Shi, G., Ruan, H., Gu, X., Liu, Z., Wu, X., Gao, X., and Xu, Y. (2010). Interaction of MAGED1 with nuclear receptors affects circadian clock function. The EMBO journal 29, 1389-1400.
He, Y., Jones, C.R., Fujiki, N., Xu, Y., Guo, B., Holder, J.L., Jr., Rossner, M.J., Nishino, S., and Fu, Y.H. (2009). The transcriptional repressor DEC2 regulates sleep length in mammals. Science 325, 866-870.
Xu, Y., Toh, K.L., Jones, C.R., Shin, J.Y., Fu, Y.H., and Ptacek, L.J. (2007). Modeling of a human circadian mutation yields insights into clock regulation by PER2. Cell 128, 59-70.
Xu, Y., Padiath, Q.S., Shapiro, R.E., Jones, C.R., Wu, S.C., Saigoh, N., Saigoh, K., Ptacek, L.J., and Fu, Y.H. (2005). Functional consequences of a CKIdelta mutation causing familial advanced sleep phase syndrome. Nature 434, 640-644.
Lee HY, Xu Y, Huang Y, Ahn AH, Auburger GW, Pandolfo M, Kwiecinski H, Grimes DA, Lang AE, Nielsen JE, Averyanov Y, Servidei S, Friedman A, Van Bogaert P, Abramowicz MJ, Bruno MK, Sorensen BF, Tang L, Fu YH, Ptacek LJ (2004). The gene for paroxysmal non-kinesigenic dyskinesia encodes an enzyme in a stress response pathway. Human molecular genetics 13, 3161-3170.
Xu, Y., Takeda, S., Nakata, T., Noda, Y., Tanaka, Y., and Hirokawa, N. (2002). Role of KIFC3 motor protein in Golgi positioning and integration. J Cell Biol 158, 293-303.
Contact Information：
703-3119, 199 Ren-Ai Road, Suzhou Industrial Park, Suzhou, Jiangsu, 215123, China
Tel: 86-512-65883781, Fax: 86-512-65883562
E-mail: yingxu@suda.edu.cn
Website :http://web.suda.edu.cn/yingxu/index.html, https://www.cam-su.org/cms/10614
