Xueguang Zhang

Professor, Director
Jiangsu Stem Cell Key Laboratory

Jiangsu Institute of Clinical Immunology

E-mail: xueguangzh@126.com


Major Research Directions:

1. Stem cell and medical bio-material.

2. Tumor immunity and autoimmune disease


Professional positions & Education:

2011- present  Director of Jiangsu Institute of Clinical Immunology

2003- present  Director of Jiangsu Stem Cell Key Laboratory

2000- present  Director of Medical Biotechnology Institute of Soochow University

2000- 2012    Vice President of Soochow University

             Director of the Key Research Institute of Clinical Immunlogy

             No.1 Affiliated Hospital of Suzhou University

1993-1999    Professor of Immunology

             Director of Immunology Research Unit

             Director of Biotechnology Institute

             Vice President of Suzhou Medical College

1991-1993    Post-doctorate

             Blood & Tumor Research Section

             Nante Medical College, France

1990-1991    Assistant Professor of Immunology

             Director of Immunology Research Unit

             Deputy director of Biotechnology Institute

1986-1990    Doctor’s degree of Molecular Biology and Immunology

             Montpellier University of Science and Technology, France

1982-1986    Lecturer

             Teaching and Research Group of Pathology and Physiology

             Suzhou Medical College

1978-1982    Master’s degree of Immunology

             Teaching and Research Group of Pathology and Physiology

             Suzhou Medical College

1974-1978    Bachelor’s degree of Medicine

             Suzhou Medical College



1993-1996 recipient of National Excellent Youth Scientific Fund

1996-2000 recipient of National Outstanding Youth Scientific Fund


Professional Organizations:

Standing Committee member of Chinese Immunology Association

Chairman of Jiangsu Immunology Association

Chairman of Jiangsu Microbiology and Immunology Branch

Member of Jiangsu Branch, Chinese Medical Association

Member of American Immunology Association

Member of American Hematology Association



1.    Gu Y, Xue Q, Chen Y, Yu G, Qing M, Shen Y, Wang M, Shi Q, Zhang X*.Different roles of PD-L1 and FasL in immunomodulation mediated by human placenta-derived mesenchymal stem cells[J]. Human Immunology, 2013, 74(3):267–276.

2.    Xue Q, Luan XY, Gu YZ, Wu HY, Zhang GB, Yu GH, Zhu HT, Wang M, Dong W, Geng YJ, Zhang XG*. The negative co-signaling molecule b7-h4 is expressed by human bone marrow-derived mesenchymal stem cells and mediates its T-cell modulatory activity. Stem Cells Dev. 2010;19:27-38.

3.    Zhang F, Lu Q, Yue X, Zuo B, Qin M, Li F, Kaplan DL, Zhang X*. 2015. Regeneration of high-quality silk fibroin fiber by wet spinning from CaCl2-formic acid solvent. Acta Biomater 12: 139-45.

4.    Zhang F, Lu Q, Ming J, Dou H, Liu Z, Zuo B*, Qin M, Li F, Kaplan DL, Zhang X*. Silk dissolution and regeneration at the nanofibril scale. J Mater Chem B 2014;2:3879-3885.

5.    Zhang F, Lu Q, Ming J, Dou H, Liu Z, Zuo B*, Qin M, Li F, Kaplan DL, Zhang X*. Silk dissolution and regeneration at the nanofibril scale. J Mater Chem B 2014;2:3879-3885.

6.    Juean Jiang, Jianhua Jiang, Cuiping Liu, Guangbo Zhang, Li Gao, Yongjing Chen, Ranran Zhu, Ting Wang, Fengmin Wang, Xueguang Zhang*, Qun Xue. Enhancement of Membrane B7-H3 Costimulatory Molecule but Reduction of Its Soluble Form in Multiple Sclerosis. Journal of Clinical Immunology. 2013; 33: 118-126.

7.    Bin Shen ,Jun ZhangHongya WuJianying Wang Ke MaZheng LiZhang X*. Generation of gene-modified mice via Cas9/RNA-mediated gene targeting[J]. Cell Research, 2013, 23.

8.    Yan-zheng Gu ,Qun Xue,Yong-jing Chen, Ge-Hua Yu, Ming-de Qing,Yu Shen, Ming-yuan Wang,Qin Shi,Xue-Guang Zhang*.Different roles of PD-L1 and FasL in immunomodulation mediated by human planceta-derived mesenchymal stem cells. Human Immunology. 201374:267-276

9.    Liang Zhang , Hongya Wu , Gang Li , Chuanyang Sun , Hui Song , Jinmei Li , Tianhang Zhai , Lv Huang , Chuansheng Hou , Weipeng Wang , Bin Zhou , Shaohua Chen , Binfeng Lu , Desheng Lu, Xueguang Zhang*. The costimulatory molecule B7-H4 promote tumor progression and cell proliferation through translocating into nucleus. Oncogene. 2013, 32:5347–5358.

10.  Wang F, Yan T, Chen L, Chen X, Liu T, Shen S, Li T, Gao L, Wang T, Sun J, Liu C, Wu H, Zhang X*, Chen L. Involvement of Inducible Costimulator Ligand (ICOSL) Expression in Thyroid Tissue in Hyperthyroidism of Graves’ Disease Patients. Journal of Clinical Immunology. 2012321253-1261.

11.  Weipeng Wang,* Jing Sun,* Fang Li, Rui Li, Yongping Gu, Cuiping Liu, Peng Yang, Ming Zhu, Lujun Chen, Wenyan Tian, Huan Zhou, Yong Mao, Liang Zhang, Jingting Jiang, Changping Wu, Dong Hua, Weichang Chen, Binfeng Lu, Jingfang Ju, and Xueguang Zhang*. A frequent somatic mutation in CD274 3’-UTR 1 leads to protein 2 over-expression in gastric cancer by disrupting miR-570 binding. Hum Mutat. 2012;33: 480-484.

12.  Xin Gao, Yibei Zhu, Gang Li, Haitao Huang, Guangbo Zhang, Fengming Wang, Jing Sun, Qianting Yang, Xueguang Zhang*, Binfeng Lu. TIM-3 Expression Characterizes Regulatory T Cells in Tumor Tissues and Is Associated with Lung Cancer Progression. PLoS ONE. 2012; 7(2): e30676.

13.  Liwen Chen, Yibei Zhu, Guangbo Zhang, Chao Gao, Weixue Zhong and Xueguang Zhang*. CD83-stimulated monocytes suppress T-cell immune responses through production of PGE2. Pro Nat1.Acad.Sci.USA. 2011;108: 18778-18783.

14.  Jing Sun, Fengqing Fu, Wenchao Gu, Ruhong Yan, Guangbo Zhang, Zhiyong Shen, Yinghui Zhou, Han Wang, Bairong Shen, Xueguang Zhang*. Origination of New Immunological Functions in the Costimulatory Molecule B7-H3: The Role of Exon Duplication in Evolution of the Immune System. PLoS ONE2011; 6(9):e24751. doi: 10.1371

15.  Lu-jun Chen, Jing Sun, Hong-ya Wu, Shu-ming Zhou, Yan Tan, Ming Tan, Bao-en Shan, Bin-feng Lu and Xue-guang Zhang*. B7-H4 expression associates with cancer progression and predicts patient’s survival in human esophageal squamous cell carcinoma. Cancer Immunol Immunother. 2011;60: 1047-1055.

16.  Jiang J, Zhu Y, Wu C, Shen Y, Wei W, Chen L, Zheng X, Sun J, Lu B, Zhang X*. Tumor expression of B7-H4 predicts poor survival of patients suffering from gastric cancer. Cancer Immunol Immunother. 2010;59:1707-1714.

17.  Zhu Y, Ju S, Chen E, Dai S, Li C, Morel P, Liu L, Zhang X*, Lu B. T-bet and Eomesodermin are required for T cell-mediated antitumor immune responses. J Immunol. 2010;185:3174-3183.

18.  Zhang G, Wang J, Kelly J, Gu G, Hou J, Zhou Y, Redmond HP, Wang JH, Zhang X*. B7-h3 augments the inflammatory response and is associated with human sepsis. J Immunol. 2010;185:3677-3684. 

19.  Sun J, Chen LJ, Zhang GB, Jiang JT, Zhu M, Tan Y, Wang HT, Lu BF, Zhang XG*. Clinical significance and regulation of the costimulatory molecule B7-H3 in human colorectal carcinoma. Cancer Immunol Immunother. 2010;59:1163-1171. 

* Corresponding author


Representative Research Supports:

2007CB512402, Zhang (In charge)                    10/01/2012 – 10/31/2017              

Sub–topics of National Basic Research Program of China(973 Program)     

 “Molecular mechanisms of self-antigen recognition by the immune system and effect on autoimmunity”


2006AA02A254, Zhang (In charge)                  01/01/2009 – 12/31/2010              

Sub–topics of National high-tech research development plan (863 plan)    

 “Optimization and reconstruction of humanized antibody”


30930085, Zhang (In charge)                                    01/01/2010 – 12/31/2013              

National Natural Science Foundation of China  

 “Biological significance of PD-1/PD-L1 pathway affected self immunologic injury of RA”