Development of nanomaterials for mRNA therapeutics and genome editing

Speaker: Prof. Yizhou Dong (College of Pharmacy, The Ohio State University, OH 43210)
Title: Development of nanomaterials for mRNA therapeutics and genome editing
Time: 9:30 AM, Aug. 2nd (Thursday)
Location: 909-B, Dushu Lake Campus
Abstract:
Messenger RNA (mRNA) based therapeutics have shown great promise for expressing functional proteins. However, efficient and safe delivery of mRNA remains a key challenge for the clinical application of mRNA based therapeutics. Recently, we developed 1,3,5-tricarboxamide lipid-derived nanoparticles for mRNA delivery. One lead nanomaterial effectively delivered factor IX mRNA in a hemophilia mouse model. In addition, this nanomaterial was capable of delivering Cas9 mRNA and guide RNA to mouse liver for genome editing. 

Biography:

Yizhou Dong is an Associate Professor at The Ohio State University. Yizhou Dong received his B.S. from Peking University, Health Science Center (2002) and M.S. from Shanghai Institute of Organic Chemistry (2005). In 2009, he received his Ph.D. degree in pharmaceutical sciences from the University of North Carolina at Chapel Hill under the supervision of Professor K.-H. Lee. From 2010 to 2014, he was a postdoctoral fellow in the laboratory of Professors Robert Langer and Daniel Anderson at MIT. Dr. Dong joined OSU College of Pharmacy as an Assistant Professor in 2014, and was promoted to Associate Professor in 2018. His research focuses on the design and development of nanotechnology platforms for the treatment of genetic disorders, infectious diseases, and cancers. Dr. Dong has authored over fifty papers and patents. Several of his inventions have been licensed and are currently under development as drug candidates for clinical trials. He is the recipient of numerous honors, including Early Career Investigator Award from the Bayer Hemophilia Awards Program, Research Awards from the National PKU Alliance, New Investigator Grant from the AAPS Foundation, Maximizing Investigators’ Research Award from the National Institute of General Medical Sciences (NIGMS), and 2017 Ohio State Early Career Innovator of the Year.