Great Breakthrough Achieved by Professor Huang Yuhui in the Researches Concerning the Microenvironment of Tumor Immunity

Funded by several projects under the National Natural Science Fund, the team led by Professor Huang Yuhui of Cyrus Tang Hematology Center has made great breakthrough in the researches concerning the microenvironment of tumor immunity, revealed a new mechanism for the therapy of checkpoint inhibitors, and proposed the idea for the first time that the perfusion function of tumor vesselsshould be considered as the marker of immunotherapy. Recently, research results have been published in periodicals like Nature Reviews Immunology and the Journal of Clinical Investigation.

 

In recent years, with the great breakthrough in the tumor immunotherapy featuring checkpoint inhibitors, we have brought hopes for us human beings in the battles against malignant tumors. However, for quite a long time, the functional mechanism of checkpoint inhibitors still remains unclear for medical workers. Meanwhile, the low efficiency of the therapy and the lack of reliable biomarkers for the evaluation and prediction of related curative effect have always been the headache for relevant researchers. By building a series of models on the carcinoma in situ of mice and IFN╬│receptor deficient mice, the research team led by Professor Huang Yuhui has proved that checkpoint inhibitors often take effects via activating T lymphocytes and triggering the normalization of tumor vessels.

 

 

The normalization of vessels could further activate the T lymphocytes by remodeling the tumor microenvironments and reducing immunosuppression. The formation of such a positive feedback loop triggers long-actingantineoplasticimmunoreactions. Besides, the research of the project team also proves that the promotion of the perfusion function of vesselsmaintains a positive correlation with the curative effect of checkpoint inhibitors. Therefore, it could be used to evaluate and predict the curative effect of checkpoint inhibitors.

 

All these research results have not only expounded the internal mechanism of the selective effect of checkpoint inhibitors, but proved the new idea that the curative effect oftumor immunitycan be predicted by monitoring the functional status of tumor vessels. Given theperfusion functionofvessels can be obtained with noninvasivemedical imaging technologies, it actually provide a brand-new thought for the fulfillment of personalized tumor immunotherapy.

 

Relevant Links:

Paper 1: https://www.nature.com/articles/nri.2017.145

Paper 2: https://www.jci.org/articles/view/96582