Soochow Scholars Published in Annals of the Rheumatic Diseases

On October 8, anresearch papernamed “Rheumatoid Arthritis Associated DNA Methylation Sites in Peripheral Blood Mononuclear Cells” written by Professor Lei Shufeng and his team was published online in Annals of the Rheumatic Diseases (IF: 12.4). The team is from Genetic Epidemics and Genomics Research Center in School of Public Health, Medical College of Soochow University. The paper points out the newly discovered etiology of rheumatoid arthritis. (Link to the paper:https://ard.bmj.com/content/early/2018/10/08/annrheumdis-2018-213970 )

Through cross-disciplinary, multi-omics and multi-disciplinary studies, Professor Lei Shufeng and his team members discovered that rheumatoid arthritis is associated with DNA methylation and abnormal expression of several interferon induced genes. When those genes are expressed abnormally, they would impact each other and form a gene regulatory network. Among them, the abnormal methylation of PARP9 may affect the duplication and activation of T-cells as well as the expression of IL2 inflammatory factors, thus influencing the process of inflammation and diseases. These discoveries have refreshedthe existing knowledge of the etiology of the rheumatoid arthritis molecules. Meanwhile, they provide molecule targets and scientific evidence for intervention and prevention of rheumatoid arthritis.

Annals of the Rheumatic Diseases is an authoritative journal in the international rheumatic field. The publication of the paper proves that Professor Lei Shufeng and his team have made an important breakthrough in this field.

The team has made several achievements in this field and some of their papers include:



1.Lin et al. Genome-wide integrative analysis identified SNP-miRNA-mRNA interaction networks in peripheral blood mononuclear cells. Epigenomics 2017;9(10):1287–1298. www.ncbi.nlm.nih.gov/pubmed/28877608



2.Xia et al. Integrative multi-omics analysis revealed SNP-lncRNA-mRNA (SLM) networks in human peripheral blood mononuclear cells. Hum Genet.2017;136(4):451-462. www.ncbi.nlm.nih.gov/pubmed/28243742



3.Mo et al. Identification and evaluation of lncRNA and mRNA integrative modules in human peripheral blood mononuclear cells. Epigenomics. 2017;9(7):943–954. www.ncbi.nlm.nih.gov/pubmed/28621149



4.Mo et al. Genome-Wide Identification of N6-Methyladenosine (m6A) SNPs Associated With Rheumatoid Arthritis. Frontiers in Genetics. 2018.doi: 10.3389/fgene.2018.00299. www.ncbi.nlm.nih.gov/pubmed/30123242



5.Xie et al. Multiple correlation analyses revealed complex relationship between DNA methylation and mRNA expression in human peripheral blood mononuclear cells. FunctIntegr Genomics. 2018;18:1–10. www.ncbi.nlm.nih.gov/pubmed/28735351



6.He et al. Identification of expression quantitative trait loci (eQTLs) in human peripheral blood mononuclear cells (PBMCs) and shared with liver and brain. J Cell Biochem. 2018; 119:1659–1669. www.ncbi.nlm.nih.gov/pubmed/28792098



7.Wang et al. Correlation analyses revealed global microRNA-mRNA expression associations in human peripheral blood mononuclear cells. Mol Genet Genomics. 2018; 293(1):95-105. www.ncbi.nlm.nih.gov/pubmed/28879530



8.Mo et al. Integrative analysis identified mediation effects of lncRNAs on the correlations between methylation and mRNA. Int J Biochem Cell Biol. 2018 Sep 15;104:66-72. www.ncbi.nlm.nih.gov/pubmed/30227253



9.Mo XB et al. Detection of lncRNA-mRNA interaction modules by integrating eQTL with weighted gene co-expression network analysis. Functional & Integrative Genomics, 2018 in press. doi: 10.1007/s10142-018-0638-4. https://www.ncbi.nlm.nih.gov/pubmed/30280282