The Molecular Imaging and Nuclear Medicine Center of State Key Laboratory Made New Progress in Therapy of Parkinson’s Disease with Biomimetic Ultrasmall Nanoparticles

Parkinson’s disease (PD) is the second most common central neurodegenerative disease. In recent years, the prevalence of Parkinson’s disease is increasing year by year in China, and the patients often have different degrees of disabilities in the late stage of the disease, which has become a serious economic and social burden. The current chemotherapy can only alleviate the symptoms of patients, and cannot prevent the progress of the disease completely.

https://dx.doi.org/10.1021/jacs.0c09390

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The Molecular Imaging and Nuclear Medicine Center of State Key Laboratory of Radiation Medicine and Protection of Soochow University endowed nanoparticles with a variety of enzyme-like activities and excellent targeting through CSPQ nanoparticles and cell membrane coating, and implemented the targeted regulation of the phenotype of microglia with nanoparticles to efficiently scavenge reactive oxygen species, thus realizing the effective treatment of Parkinson’s disease. The related achievements were published with the title of “Targeting Microglia for Therapy of Parkinson’s Disease by Using Biomimetic Ultrasmall Nanoparticles ” in J. am. Chem. SOC Journal, and selected as the cover paper.

State Key Laboratory of Radiation Medicine and Protection of Soochow University was the first unit of the paper with PhD Candidate Liu Hanghang being the first author and Professor Li Zhen being the corresponding author. The paper was supported by national, provincial and municipal funds.