Recently, Professor Yin Lichen’s team from College of Nano Science & Technology developed a pre-osteoclast membrane-coated nanodecoy (RAW-PLGA) for the treatment of postmenopausal osteoporosis. This is the first time that cell membrane nanotechnology has been used for osteoporosis treatment, and it is also the first report of using cell membrane to clear RANKL. Therefore, this biomimetic nanomaterial provides an effective strategy for restoring osteoclast/osteoblast balance, and provides a new idea for the clinical treatment of postmenopausal osteoporosis. The related results were published in Science Advances (Sci. Adv. .2021, 7, abl6432)

Link：https://www.science.org/doi/10.1126/sciadv.abl6432

Title：Cytokine-scavenging nanodecoys reconstruct osteoclast/osteoblast balance toward the treatment of postmenopausal osteoporosis

Authors：Yang Zhou, Yekun Deng, Zhongmin Liu, Mengyuan Yin, Mengying Hou, Ziyin Zhao, Xiaozhong Zhou, Lichen Yin*

Sponsorship：This study was supported by The National Natural Science Foundation of China (51873142), Collaborative Innovation Center of Suzhou Nano Science & Technology, The 111 project, and Joint International Research Laboratory of Carbon-Based Functional Materials and Devices.