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Research Team Led by Professor Zhou Ruhong at RAD-X of Soochow University Discovers New Immunological Responses




It is a completely new field to carry drug molecules with nanophase materials into certain cells of organism. In order to target the drug at the tumor, a former study shows that with the help of a nanophase like graphene, drug molecules or vaccines can be transported to where the tumor is and be released to treat the tumor cells. Besides, biocompatibility of the nanophase materials can be improved by passivation with polymers.

Professor Zhou Ruhong and his research team at RAD-X of Soochow University work with scholars including Ma Guanghui at Chinese Science Academy. The results of their cooperative research have been published on Nature Communications with the title of “PEGylated Graphene Oxide Elicits Strong Immunological Responses Despite Surface Passivation.”

The research team led by Professor Zhou discovers that the immune response in soma can be intensely triggered by the nanophase materials coated with polymers, which has never been reported before. However, all the polymers-coated materials are not bound to impair human bodies. The soma will signal for help whenever realizing the approach of the drug, meanwhile, immune cells will take action at once and move near the place where invasion is launched. What's more, the signals will be sent within 6 hours after the cells meet the drug. The results of their research were published on Nature Communications with the title of “PEGylated Graphene Oxide Elicits Strong Immunological Responses Despite Surface Passivation.”

In addition, Professor Zhou and his cooperators also find a new method of activating the immune cells as well as having them reacted. Without causing any physical damage to the cells, the polymers-coated graphene can stimulate them to signal and make the immune system response, which is by no means easy before this research.